The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery
M Bern, KMK Sand, J Nilsen, I Sandlie… - Journal of Controlled …, 2015 - Elsevier
M Bern, KMK Sand, J Nilsen, I Sandlie, JT Andersen
Journal of Controlled Release, 2015•ElsevierAlbumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it
binds a range of medical drugs. It has an unusually long serum half-life of almost 3 weeks,
and although the structure and function of albumin has been studied for decades, a
biological explanation for the long half-life has been lacking. Now, recent research has
unravelled that albumin-binding cellular receptors play key roles in the homeostatic …
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it
binds a range of medical drugs. It has an unusually long serum half-life of almost 3 weeks,
and although the structure and function of albumin has been studied for decades, a
biological explanation for the long half-life has been lacking. Now, recent research has
unravelled that albumin-binding cellular receptors play key roles in the homeostatic …
Abstract
Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it binds a range of medical drugs. It has an unusually long serum half-life of almost 3 weeks, and although the structure and function of albumin has been studied for decades, a biological explanation for the long half-life has been lacking. Now, recent research has unravelled that albumin-binding cellular receptors play key roles in the homeostatic regulation of albumin. Here, we review our current understanding of albumin homeostasis with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin–megalin complex, and we discuss their importance on uses of albumin in drug delivery.
Elsevier