TCR clonotypes: molecular determinants of T-cell efficacy against HIV
A Lissina, LA Chakrabarti, M Takiguchi… - Current opinion in virology, 2016 - Elsevier
Highlights•HIV-specific CD8+ T-cells show TCR immunodominance patterns and public
clonotypes.•TCR avidity is a major determinant of CD8+ T-cell functional efficacy against
HIV.•Crossreactive clonotypes are key to adapt to HIV evolution and control the virus.•High
affinity public clonotypes shape CD4+ T-cell responses in HIV controllers.Because of the
enormous complexity and breadth of the overall HIV-specific CD8+ T-cell response,
invaluable information regarding important aspects of T-cell efficacy against HIV can be …
clonotypes.•TCR avidity is a major determinant of CD8+ T-cell functional efficacy against
HIV.•Crossreactive clonotypes are key to adapt to HIV evolution and control the virus.•High
affinity public clonotypes shape CD4+ T-cell responses in HIV controllers.Because of the
enormous complexity and breadth of the overall HIV-specific CD8+ T-cell response,
invaluable information regarding important aspects of T-cell efficacy against HIV can be …