[HTML][HTML] Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
T Kitamuro, K Takahashi, K Ogawa… - Journal of Biological …, 2003 - ASBMB
Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various
environmental factors, which represents a protective response against oxidative stresses.
Here we show that hypoxia represses HO-1 expression in three human cell types but
induces it in rat, bovine, and monkey cells, indicating the inter-species difference in the
hypoxic regulation of HO-1 expression. The hypoxia-mediated repression of HO-1 …
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various
environmental factors, which represents a protective response against oxidative stresses.
Here we show that hypoxia represses HO-1 expression in three human cell types but
induces it in rat, bovine, and monkey cells, indicating the inter-species difference in the
hypoxic regulation of HO-1 expression. The hypoxia-mediated repression of HO-1 …