[HTML][HTML] A novel, blocking, Fc-silent anti-CD40 monoclonal antibody prolongs nonhuman primate renal allograft survival in the absence of B cell depletion
F Cordoba, G Wieczorek, M Audet, L Roth… - American Journal of …, 2015 - Elsevier
CD40–CD154 pathway blockade prolongs renal allograft survival in nonhuman primates
(NHPs). However, antibodies targeting CD154 were associated with an increased incidence
of thromboembolic complications. Antibodies targeting CD40 prolong renal allograft survival
in NHPs without thromboembolic events but with accompanying B cell depletion, raising the
question of the relative contribution of B cell depletion to the efficacy of anti-CD40 blockade.
Here, we investigated whether fully silencing Fc effector functions of an anti-CD40 antibody …
(NHPs). However, antibodies targeting CD154 were associated with an increased incidence
of thromboembolic complications. Antibodies targeting CD40 prolong renal allograft survival
in NHPs without thromboembolic events but with accompanying B cell depletion, raising the
question of the relative contribution of B cell depletion to the efficacy of anti-CD40 blockade.
Here, we investigated whether fully silencing Fc effector functions of an anti-CD40 antibody …
