[HTML][HTML] A short sequence motif in the 5′ leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication
N Van Bel, AT Das, M Cornelissen, TEM Abbink… - Journal of Biological …, 2014 - ASBMB
The 5′ leader of the HIV-1 RNA genome encodes signals that control various steps in the
replication cycle, including the dimerization initiation signal (DIS) that triggers RNA
dimerization. The DIS folds a hairpin structure with a palindromic sequence in the loop that
allows RNA dimerization via intermolecular kissing loop (KL) base pairing. The KL dimer
can be stabilized by including the DIS stem nucleotides in the intermolecular base pairing,
forming an extended dimer (ED). The role of the ED RNA dimer in HIV-1 replication has …
replication cycle, including the dimerization initiation signal (DIS) that triggers RNA
dimerization. The DIS folds a hairpin structure with a palindromic sequence in the loop that
allows RNA dimerization via intermolecular kissing loop (KL) base pairing. The KL dimer
can be stabilized by including the DIS stem nucleotides in the intermolecular base pairing,
forming an extended dimer (ED). The role of the ED RNA dimer in HIV-1 replication has …
