PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters
JM Gerlach, M Furrer, M Gallant… - Proceedings of the …, 2017 - National Acad Sciences
JM Gerlach, M Furrer, M Gallant, D Birkel, A Baluapuri, E Wolf, P Gallant
Proceedings of the National Academy of Sciences, 2017•National Acad SciencesThe Myc oncogene is a transcription factor with a powerful grip on cellular growth and
proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively
characterized, but it is less clear whether this sequence-specific interaction is sufficient for
Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and
specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the
PAF1 complex is typically associated with active genes, this interaction with Leo1 …
proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively
characterized, but it is less clear whether this sequence-specific interaction is sufficient for
Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and
specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the
PAF1 complex is typically associated with active genes, this interaction with Leo1 …
The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc’s binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
National Acad Sciences