Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta)
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging,
ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in
mice can destroy up to∼ 50% of synapses between auditory nerve fibers (ANFs) and inner
hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the
synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs
temporal processing and hearing-in-noise, a classic complaint of those with sensorineural …
ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in
mice can destroy up to∼ 50% of synapses between auditory nerve fibers (ANFs) and inner
hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the
synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs
temporal processing and hearing-in-noise, a classic complaint of those with sensorineural …