Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells
Y Ji, K Li, X Xiao, S Zheng, T Xu, S Chen - Journal of pediatric surgery, 2012 - Elsevier
BACKGROUND/PURPOSE: Propranolol, a non-selective beta-blocker, has recently been
introduced as a novel treatment modality for proliferating hemangiomas. However, the
mechanism of action of this therapy is unknown. In this study, we investigated propranolol in
the etiology of hemangiomas that are associated with the proliferation and apoptosis of
hemangioma-derived endothelial cells (HemECs). METHODS: HemECs were isolated from
freshly resected hemangioma specimens. We studied propranolol-treated HemECs in vitro …
introduced as a novel treatment modality for proliferating hemangiomas. However, the
mechanism of action of this therapy is unknown. In this study, we investigated propranolol in
the etiology of hemangiomas that are associated with the proliferation and apoptosis of
hemangioma-derived endothelial cells (HemECs). METHODS: HemECs were isolated from
freshly resected hemangioma specimens. We studied propranolol-treated HemECs in vitro …