Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression
B Sun, C Dong, H Lei, Y Gong, M Li, Y Zhang… - Chemico-Biological …, 2020 - Elsevier
Hemangioma is one of the commonest benign vascular tumors among children. Propranolol
is the first-line therapeutic drug for hemangioma. However, the effects and mechanisms of
propranolol in hemangioma have not been thoroughly elaborated. In this study, the effects
and mechanisms of propranolol were explored using hemangioma-derived endothelial cells
(HemECs). The expression of GLUT1 were determined by immunofluorescence staining.
qRT-PCR assay was conducted to detect the mRNA expressions of angiopoietin-2 (Ang-2) …
is the first-line therapeutic drug for hemangioma. However, the effects and mechanisms of
propranolol in hemangioma have not been thoroughly elaborated. In this study, the effects
and mechanisms of propranolol were explored using hemangioma-derived endothelial cells
(HemECs). The expression of GLUT1 were determined by immunofluorescence staining.
qRT-PCR assay was conducted to detect the mRNA expressions of angiopoietin-2 (Ang-2) …