Systems biology of oxygen homeostasis
D Samanta, NR Prabhakar… - … : Systems Biology and …, 2017 - Wiley Online Library
D Samanta, NR Prabhakar, GL Semenza
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2017•Wiley Online LibraryMetazoan species maintain oxygen homeostasis through the activity of hypoxia‐inducible
factors, which are transcriptional activators that regulate the expression of hundreds of
genes to match O2 supply and demand. Here, we review the involvement of hypoxia‐
inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing,
O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9: e1382.
doi: 10.1002/wsbm. 1382 This article is categorized under: Biological Mechanisms> …
factors, which are transcriptional activators that regulate the expression of hundreds of
genes to match O2 supply and demand. Here, we review the involvement of hypoxia‐
inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing,
O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9: e1382.
doi: 10.1002/wsbm. 1382 This article is categorized under: Biological Mechanisms> …
Metazoan species maintain oxygen homeostasis through the activity of hypoxia‐inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia‐inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382
This article is categorized under:
- Biological Mechanisms > Metabolism
- Physiology > Mammalian Physiology in Health and Disease
- Physiology > Organismal Responses to Environment
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