Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism
C Niu, LI Li, S Daffis, J Lucifora, M Bonnin… - Journal of …, 2018 - Elsevier
Background & Aims GS-9620, an oral agonist of toll-like receptor 7 (TLR7), is in clinical
development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown
to induce prolonged suppression of serum viral DNA and antigens in the woodchuck and
chimpanzee models of CHB. Herein, we investigated the molecular mechanisms that
contribute to the antiviral response to GS-9620 using in vitro models of hepatitis B virus
(HBV) infection. Methods Cryopreserved primary human hepatocytes (PHH) and …
development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown
to induce prolonged suppression of serum viral DNA and antigens in the woodchuck and
chimpanzee models of CHB. Herein, we investigated the molecular mechanisms that
contribute to the antiviral response to GS-9620 using in vitro models of hepatitis B virus
(HBV) infection. Methods Cryopreserved primary human hepatocytes (PHH) and …
