Impact of hepatitis B virus coinfection on human T-lymphotropic virus type 1 clonality in an indigenous population of Central Australia
The Journal of infectious diseases, 2019•academic.oup.com
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus
(HBV) coinfection is high in certain Indigenous Australian populations, but its impact on
HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with
HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral
load, but there was a significant increase in clonal expansion of HTLV-1–infected
lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was …
(HBV) coinfection is high in certain Indigenous Australian populations, but its impact on
HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with
HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral
load, but there was a significant increase in clonal expansion of HTLV-1–infected
lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was …
Abstract
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1–infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1–associated malignant disease.
Oxford University Press