Can an immune-regulatory vaccine prevent HIV infection?
T Boettler, E Cunha-Neto, J Kalil… - Expert Review of Anti …, 2012 - Taylor & Francis
T Boettler, E Cunha-Neto, J Kalil, M Von Herrath
Expert Review of Anti-infective Therapy, 2012•Taylor & FrancisDeveloping vaccines to prevent the establishment of HIV infection has been fraught with
difficulties. It might therefore be important to consider other new strategies. Since several
studies suggest that anti-inflammatory stimuli can protect from HIV infection and because
HIV replicates preferably in activated T cells, we suggest here that the reduction of immune
activation through a HIV-specific regulatory T-cell vaccine might thwart early viral replication.
Thus, because immune activation is a good predictor of disease progression and the …
difficulties. It might therefore be important to consider other new strategies. Since several
studies suggest that anti-inflammatory stimuli can protect from HIV infection and because
HIV replicates preferably in activated T cells, we suggest here that the reduction of immune
activation through a HIV-specific regulatory T-cell vaccine might thwart early viral replication.
Thus, because immune activation is a good predictor of disease progression and the …
Developing vaccines to prevent the establishment of HIV infection has been fraught with difficulties. It might therefore be important to consider other new strategies. Since several studies suggest that anti-inflammatory stimuli can protect from HIV infection and because HIV replicates preferably in activated T cells, we suggest here that the reduction of immune activation through a HIV-specific regulatory T-cell vaccine might thwart early viral replication. Thus, because immune activation is a good predictor of disease progression and the immune activation set point has been shown to be an early event during HIV infection, vaccinating to achieve control of early virus-specific immune activation might be advantageous.
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