Animal models for microbicide studies
RS Veazey, RJ Shattock, P Johan Klasse… - Current HIV …, 2012 - ingentaconnect.com
RS Veazey, RJ Shattock, P Johan Klasse, JP Moore
Current HIV research, 2012•ingentaconnect.comThere have been encouraging recent successes in the development of safe and effective
topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-
retroviral drugs. However, much work remains to be accomplished before a microbicide
becomes a standard element of prevention science strategies. Animal models should
continue to play an important role in pre-clinical testing, with emphasis on safety,
pharmacokinetic and efficacy testing.
topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-
retroviral drugs. However, much work remains to be accomplished before a microbicide
becomes a standard element of prevention science strategies. Animal models should
continue to play an important role in pre-clinical testing, with emphasis on safety,
pharmacokinetic and efficacy testing.
There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.
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