[HTML][HTML] Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
M Ohtsuji, F Katsuoka, A Kobayashi, H Aburatani… - Journal of Biological …, 2008 - ASBMB
Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that
commonly contains a unique basic-leucine zipper domain. Among CNC family members,
Nrf2 is known to regulate a battery of antioxidant and xenobiotic-metabolizing enzyme
genes through the antioxidant response element (ARE). Although Nrf1 has also been shown
to bind the ARE, it is unclear whether it plays a distinct role from Nrf2 in regulating genes
with this element. To address this issue in vivo, we generated mice bearing a hepatocyte …
commonly contains a unique basic-leucine zipper domain. Among CNC family members,
Nrf2 is known to regulate a battery of antioxidant and xenobiotic-metabolizing enzyme
genes through the antioxidant response element (ARE). Although Nrf1 has also been shown
to bind the ARE, it is unclear whether it plays a distinct role from Nrf2 in regulating genes
with this element. To address this issue in vivo, we generated mice bearing a hepatocyte …
