Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus
Despite the success of targeted therapies in managing immune-mediated inflammatory
diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in
SLE are widely recognized. In the past 2 years, exciting insights supporting previous lines of
evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular
importance as IL-17 blockers have now moved successfully into the clinical space, as
illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also …
diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in
SLE are widely recognized. In the past 2 years, exciting insights supporting previous lines of
evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular
importance as IL-17 blockers have now moved successfully into the clinical space, as
illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also …
