Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver
SF Wieland, S Asabe, RE Engle, RH Purcell… - Journal of …, 2014 - Am Soc Microbiol
SF Wieland, S Asabe, RE Engle, RH Purcell, FV Chisari
Journal of virology, 2014•Am Soc MicrobiolWe compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C
virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I
interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed
and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes
was drastically reduced. These results suggest that establishment of HBV infection and its
replication space is limited by the antiviral effects of type I interferon in the chronically HCV …
virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I
interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed
and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes
was drastically reduced. These results suggest that establishment of HBV infection and its
replication space is limited by the antiviral effects of type I interferon in the chronically HCV …
Abstract
We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.
American Society for Microbiology