[HTML][HTML] Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation
Obesity is associated with hepatic steatosis, partially due to increased lipogenesis and
decreased fatty acid β-oxidation in the liver; however, the underlying mechanism of
abnormal lipid metabolism is not fully understood. We reported previously that obesity is
associated with LCN13 (lipocalin 13) deficiency. LCN13 is a lipocalin family member
involved in glucose metabolism, and LCN13 deficiency appears to contribute to
hyperglycemia in obese mice. Here, we show that LCN13 is also an important regulator of …
decreased fatty acid β-oxidation in the liver; however, the underlying mechanism of
abnormal lipid metabolism is not fully understood. We reported previously that obesity is
associated with LCN13 (lipocalin 13) deficiency. LCN13 is a lipocalin family member
involved in glucose metabolism, and LCN13 deficiency appears to contribute to
hyperglycemia in obese mice. Here, we show that LCN13 is also an important regulator of …
