[HTML][HTML] Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury
Ser/Thr kinase NIK (NF-κB-inducing kinase) mediates the activation of the noncanonical NF-
κB2 pathway, and it plays an important role in regulating immune cell development and liver
homeostasis. NIK levels are extremely low in quiescent cells due to ubiquitin/proteasome-
mediated degradation, and cytokines stimulate NIK activation through increasing NIK
stability; however, regulation of NIK stability is not fully understood. Here we identified CHIP
(carboxyl terminus of HSC70-interacting protein) as a new negative regulator of NIK. CHIP …
κB2 pathway, and it plays an important role in regulating immune cell development and liver
homeostasis. NIK levels are extremely low in quiescent cells due to ubiquitin/proteasome-
mediated degradation, and cytokines stimulate NIK activation through increasing NIK
stability; however, regulation of NIK stability is not fully understood. Here we identified CHIP
(carboxyl terminus of HSC70-interacting protein) as a new negative regulator of NIK. CHIP …