Biomarkers of operational tolerance following kidney transplantation–The immune tolerance network studies of spontaneously tolerant kidney transplant recipients
KA Newell, AB Adams, LA Turka - Human immunology, 2018 - Elsevier
Studies of kidney transplant recipients who have developed spontaneous and sustained
tolerance have revealed an association with B cells. Unexpectedly tolerant individuals are
characterized by increased numbers and frequencies of B cells in the blood and increased
expression of genes associated with B cells in the blood and urine. Comparisons of the B
cell repertoires of tolerant individuals and those receiving immunosuppression reveal that
not only are the B cells more numerous but developmental differences result in a repertoire …
tolerance have revealed an association with B cells. Unexpectedly tolerant individuals are
characterized by increased numbers and frequencies of B cells in the blood and increased
expression of genes associated with B cells in the blood and urine. Comparisons of the B
cell repertoires of tolerant individuals and those receiving immunosuppression reveal that
not only are the B cells more numerous but developmental differences result in a repertoire …
