Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil …
N Sheron, G Bird, J Koskinas, B Portmann, M Ceska… - Hepatology, 1993 - journals.lww.com
Acute alcoholic hepatitis is characterized by a unique degree of liver neutrophil infiltration,
often accompanied by marked peripheral neutrophilia in the absence of demonstrable
bacterial or fungal infection. In this study we assayed plasma and tissue levels of a potent
neutrophil activator and chemotaxin, interleukin-8, in patients with a spectrum of alcoholic
liver diseases and in normal and diseased control subjects. Levels of circulating interleukin-
8 were undetectable in normal subjects but highly elevated in patients with alcoholic …
often accompanied by marked peripheral neutrophilia in the absence of demonstrable
bacterial or fungal infection. In this study we assayed plasma and tissue levels of a potent
neutrophil activator and chemotaxin, interleukin-8, in patients with a spectrum of alcoholic
liver diseases and in normal and diseased control subjects. Levels of circulating interleukin-
8 were undetectable in normal subjects but highly elevated in patients with alcoholic …