[HTML][HTML] PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins
We have identified a new mammalian protein arginine N-methyltransferase, PRMT5,
formerly designated Janus kinase-binding protein 1, that can catalyze the formation of ω-N G-
monomethylarginine and symmetric ω-NG, NG′-dimethylarginine in a variety of proteins. A
hemagglutinin peptide-tagged PRMT5 complex purified from human HeLa cells catalyzes
theS-adenosyl-l-[methyl-3 H] methionine-dependentin vitro methylation of myelin basic
protein. When the radiolabeled myelin basic protein was acid-hydrolyzed to free amino …
formerly designated Janus kinase-binding protein 1, that can catalyze the formation of ω-N G-
monomethylarginine and symmetric ω-NG, NG′-dimethylarginine in a variety of proteins. A
hemagglutinin peptide-tagged PRMT5 complex purified from human HeLa cells catalyzes
theS-adenosyl-l-[methyl-3 H] methionine-dependentin vitro methylation of myelin basic
protein. When the radiolabeled myelin basic protein was acid-hydrolyzed to free amino …
