Retinoic acid-related Orphan Receptor γ (RORγ): connecting sterol metabolism to regulation of the immune system and autoimmune disease
AM Jetten, Y Takeda, A Slominski, HS Kang - Current opinion in toxicology, 2018 - Elsevier
Cholesterol and its metabolites are bioactive lipids that interact with and regulate the activity
of various proteins and signaling pathways that are implicated in the control of a variety of
physiological and pathological processes. Recent studies revealed that retinoic acid-related
orphan receptors, RORα and γ, members of the ligand-dependent nuclear receptor
superfamily, exhibit quite a wide binding specificity for a number of sterols. Several
cholesterol intermediates and metabolites function as natural ligands of RORα and RORγ …
of various proteins and signaling pathways that are implicated in the control of a variety of
physiological and pathological processes. Recent studies revealed that retinoic acid-related
orphan receptors, RORα and γ, members of the ligand-dependent nuclear receptor
superfamily, exhibit quite a wide binding specificity for a number of sterols. Several
cholesterol intermediates and metabolites function as natural ligands of RORα and RORγ …
