[HTML][HTML] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells
M Maggiolini, A Vivacqua, G Fasanella… - Journal of Biological …, 2004 - ASBMB
A growing body of evidence concerning estrogen effects cannot be explained by the classic
model of hormone action, which involves the binding to estrogen receptors (ERs) α and ERβ
and the interaction of the steroid-receptor complex with specific DNA sequences associated
with target genes. Using c-fos proto-oncogene expression as an early molecular sensor of
estrogen action in ERα-positive MCF7 and ER-negative SKBR3 breast cancer cells, we
have discovered that 17β-estradiol (E2), and the two major phytoestrogens, genistein and …
model of hormone action, which involves the binding to estrogen receptors (ERs) α and ERβ
and the interaction of the steroid-receptor complex with specific DNA sequences associated
with target genes. Using c-fos proto-oncogene expression as an early molecular sensor of
estrogen action in ERα-positive MCF7 and ER-negative SKBR3 breast cancer cells, we
have discovered that 17β-estradiol (E2), and the two major phytoestrogens, genistein and …