IL-4 induces production of the lung collectin surfactant protein-D
Y Cao, JQ Tao, SR Bates, MF Beers… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Surfactant protein (SP)-D is an epithelial cell product of the distal air
spaces that aids uptake and clearance of inhaled pathogens and allergens. Allergic airway
inflammation significantly increases SP-D levels in the bronchoalveolar lavage fluid in
asthmatic patients and mouse models, but the mechanisms involved remain unknown.
OBJECTIVE: To investigate the effects of the TH2-type cytokine IL-4 on SP-D production by
isolated pulmonary epithelial cells. METHODS: Rat type II alveolar epithelial cells were …
spaces that aids uptake and clearance of inhaled pathogens and allergens. Allergic airway
inflammation significantly increases SP-D levels in the bronchoalveolar lavage fluid in
asthmatic patients and mouse models, but the mechanisms involved remain unknown.
OBJECTIVE: To investigate the effects of the TH2-type cytokine IL-4 on SP-D production by
isolated pulmonary epithelial cells. METHODS: Rat type II alveolar epithelial cells were …
