The development of easily accessible tools for human immunophenotyping to classify
patients into discrete disease endotypes is advancing personalized therapy. However, no
systematic approach has been developed for the study of inflammatory lung diseases with
often complex and highly heterogeneous disease etiologies. We have devised an internally
standardized flow cytometry approach that can identify parallel inflammatory alveolar
macrophage phenotypes in both the mouse and human lungs. In mice, lung innate immune …