[HTML][HTML] Systemic white blood cell count as a biomarker associated with severity of chronic obstructive lung disease
HK Koo, HK Kang, P Song, HK Park… - Tuberculosis and …, 2017 - ncbi.nlm.nih.gov
HK Koo, HK Kang, P Song, HK Park, SS Lee, H Jung
Tuberculosis and respiratory diseases, 2017•ncbi.nlm.nih.govBackground Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory
disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity
of COPD, independent of other inflammatory conditions, such as metabolic syndrome.
Methods The WBC counts were compared between 1227 COPD patients and 8679 non-
COPD adults older than 40. The relationships between the WBC count, lung function, and
symptoms score in COPD patients, were determined, using general linear regression …
disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity
of COPD, independent of other inflammatory conditions, such as metabolic syndrome.
Methods The WBC counts were compared between 1227 COPD patients and 8679 non-
COPD adults older than 40. The relationships between the WBC count, lung function, and
symptoms score in COPD patients, were determined, using general linear regression …
Abstract
Background
Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome.
Methods
The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses.
Results
The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second (FEV 1, L), and FEV 1 (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count.
Conclusion
The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.
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