Neural innervation of white adipose tissue and the control of lipolysis
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its
activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-
executed SNS–norepinephrine (NE)-mediated WAT lipolysis is dependent on β-
adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A
phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically
and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific …
activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-
executed SNS–norepinephrine (NE)-mediated WAT lipolysis is dependent on β-
adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A
phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically
and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific …