Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

I Tabas, D Ron - Nature cell biology, 2011 - nature.com
Nature cell biology, 2011nature.com
The ability to respond to perturbations in endoplasmic reticulum (ER) function is a
fundamentally important property of all cells, but ER stress can also lead to apoptosis. In
settings of chronic ER stress, the associated apoptosis may contribute to pathophysiological
processes involved in a number of prevalent diseases, including neurodegenerative
diseases, diabetes, atherosclerosis and renal disease. The molecular mechanisms linking
ER stress to apoptosis are the topic of this review, with emphases on relevance to …
Abstract
The ability to respond to perturbations in endoplasmic reticulum (ER) function is a fundamentally important property of all cells, but ER stress can also lead to apoptosis. In settings of chronic ER stress, the associated apoptosis may contribute to pathophysiological processes involved in a number of prevalent diseases, including neurodegenerative diseases, diabetes, atherosclerosis and renal disease. The molecular mechanisms linking ER stress to apoptosis are the topic of this review, with emphases on relevance to pathophysiology and integration and complementation among the various apoptotic pathways induced by ER stress.
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