Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway

M Boca, G Distefano, F Qian, AK Bhunia… - Journal of the …, 2006 - journals.lww.com
Abstract Polycystin-1 (PC-1), the PKD1 gene product, is a large receptor whose expression
in renal epithelial cells results in resistance to apoptosis and tubulogenesis, a model
consistent with the phenotype observed in patients. This study links PC-1 expression to a
signaling pathway that is known to be both antiapoptotic and important for normal
tubulogenesis. This study found that PC-1 expression results in phosphorylation of Akt and
downstream effectors and that phosphatidylinositol 3-kinase (PI3-K) inhibitors prevent this …