Primary and secondary lymphatic valve development: molecular, functional and mechanical insights

E Bazigou, JT Wilson, JE Moore Jr - Microvascular research, 2014 - Elsevier
Fluid homeostasis in vertebrates critically relies on the lymphatic system forming a
hierarchical network of lymphatic capillaries and collecting lymphatics, for the efficient
drainage and transport of extravasated fluid back to the cardiovascular system. Blind-ended
lymphatic capillaries employ specialized junctions and anchoring filaments to encourage a
unidirectional flow of the interstitial fluid into the initial lymphatic vessels, whereas collecting
lymphatics are responsible for the active propulsion of the lymph to the venous circulation …