The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

G Krapivinsky, EA Gordon, K Wickman, B Velimirović… - Nature, 1995 - nature.com
G Krapivinsky, EA Gordon, K Wickman, B Velimirović, L Krapivinsky, DE Clapham
Nature, 1995nature.com
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium
(K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-
subunits. It has been assumed that the inwardly rectifying K+-channel gene, GIRK1, alone
encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly
rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.
Abstract
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K+-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.
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