[HTML][HTML] Syntaxin 16 binds to cystic fibrosis transmembrane conductance regulator and regulates its membrane trafficking in epithelial cells

HY Gee, BL Tang, KH Kim, MG Lee - Journal of biological chemistry, 2010 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) is a key membrane protein
in the complex network of epithelial ion transporters regulating epithelial permeability.
Syntaxins are one of the major determinants in the intracellular trafficking and membrane
targeting of secretory proteins. In the present study we demonstrate the biochemical and
functional association between CFTR and syntaxin 16 (STX16) that mediates vesicle
transport within the early/late endosomes and trans-Golgi network. Immunoprecipitation …