Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice
M Bonaconsa, G Malpeli, A Montaruli… - Experimental …, 2014 - Elsevier
Studies on the molecular clockwork during aging have been hitherto addressed to core
clock genes. These previous investigations indicate that circadian profiles of core clock gene
expression at an advanced age are relatively preserved in the master circadian pacemaker
and the hypothalamic suprachiasmatic nucleus (SCN), and relatively impaired in peripheral
tissues. It remains to be clarified whether the effects of aging are confined to the primary loop
of core clock genes, or also involve secondary clock loop components, including Rev-erbα …
clock genes. These previous investigations indicate that circadian profiles of core clock gene
expression at an advanced age are relatively preserved in the master circadian pacemaker
and the hypothalamic suprachiasmatic nucleus (SCN), and relatively impaired in peripheral
tissues. It remains to be clarified whether the effects of aging are confined to the primary loop
of core clock genes, or also involve secondary clock loop components, including Rev-erbα …