[HTML][HTML] Post-illumination pupil response in subjects without ocular disease
L Kankipati, CA Girkin… - … ophthalmology & visual …, 2010 - iovs.arvojournals.org
Investigative ophthalmology & visual science, 2010•iovs.arvojournals.org
Purpose.: A sustained pupilloconstriction is often observed after the cessation of a bright
visual stimulus. This post-illumination pupil response (PIPR) is produced by the intrinsically
photosensitive retinal ganglion cells (ipRGCs). The present study was designed to examine
the characteristics of the PIPR in a normal population without ocular disease. Methods.:
Thirty-seven subjects (mean age, 48.6 years) were tested by presenting a 60, 10-second
light stimulus (13 log quanta/cm 2/s retinal irradiance) and recording pupillary responses for …
visual stimulus. This post-illumination pupil response (PIPR) is produced by the intrinsically
photosensitive retinal ganglion cells (ipRGCs). The present study was designed to examine
the characteristics of the PIPR in a normal population without ocular disease. Methods.:
Thirty-seven subjects (mean age, 48.6 years) were tested by presenting a 60, 10-second
light stimulus (13 log quanta/cm 2/s retinal irradiance) and recording pupillary responses for …
Abstract
Purpose.: A sustained pupilloconstriction is often observed after the cessation of a bright visual stimulus. This post-illumination pupil response (PIPR) is produced by the intrinsically photosensitive retinal ganglion cells (ipRGCs). The present study was designed to examine the characteristics of the PIPR in a normal population without ocular disease.
Methods.: Thirty-seven subjects (mean age, 48.6 years) were tested by presenting a 60, 10-second light stimulus (13 log quanta/cm 2/s retinal irradiance) and recording pupillary responses for 50 seconds after light cessation. The light stimuli (470 [blue] and 623 [red] nm) were presented by an optical system to one eye after dilation, while the consensual pupil response of the fellow, undilated eye was recorded by infrared pupillometry.
Results.: A positive PIPR was seen in all subjects tested. The population average of the PIPR for 470-nm light was 1.5 mm (SEM 0.10, P< 0.05) and the net PIPR (blue PIPR minus red PIPR) was 1.4 mm (SEM 0.09, P< 0.0001). The net PIPR correlated positively with baseline pupil diameter (P< 0.05), but not significantly with age, race, or sex (P> 0.05) in the test population.
Conclusions.: All normal subjects displayed a significant PIPR for a 10-second, 470-nm light stimulus, but not a 623-nm stimulus, which is consistent with the proposed melanopsin-mediated response. In most normal individuals, the amplitude of the PIPR was substantial. This test has the potential to be used as a tool in evaluating subjects with inner retinal dysfunction or melanopsin-related disorders.
ARVO Journals