[HTML][HTML] Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 …
C Wietek, SM Miggin, CA Jefferies… - Journal of Biological …, 2003 - ASBMB
Interferon regulatory factor (IRF) 3 is a transcription factor that binds the interferon-sensitive
response element (ISRE) and is activated by Toll-like receptor 3 (TLR3) and TLR4. We have
found that a dominant negative form of IκB kinase 2 and a mutant form of IκB, which acts as a
super-repressor of NF-κB, blocked activation of the ISRE by the TLR4 ligand
lipopolysaccharide but not the TLR3 ligand poly (IC). TLR4 failed to activate the ISRE in
mouse embryonic fibroblasts bearing a targeted deletion of p65, whereas the response to …
response element (ISRE) and is activated by Toll-like receptor 3 (TLR3) and TLR4. We have
found that a dominant negative form of IκB kinase 2 and a mutant form of IκB, which acts as a
super-repressor of NF-κB, blocked activation of the ISRE by the TLR4 ligand
lipopolysaccharide but not the TLR3 ligand poly (IC). TLR4 failed to activate the ISRE in
mouse embryonic fibroblasts bearing a targeted deletion of p65, whereas the response to …