[CITATION][C] Insulin resistance with low cellular IRS‐1 expression is also associated with low GLUT4 expression and impaired insulin‐stimulated glucose transport 1
EÉ Carvalho, P Jansson, I Nagaev… - The FASEB …, 2001 - Wiley Online Library
EÉ Carvalho, P Jansson, I Nagaev, A Wenthzel, U Smith
The FASEB journal, 2001•Wiley Online LibraryLow expression of the key docking protein insulin receptor substrate-1 (IRS-1) has been
found in fat cells from type 2 diabetic subjects as well as a cohort of non-diabetic but insulin-
resistant individuals. In this study, we examined the in vivo phenotypes as well as the insulin
signaling and action in cells from healthy subjects characterized as having normal or low
(50% of normal) IRS-1 expression.
found in fat cells from type 2 diabetic subjects as well as a cohort of non-diabetic but insulin-
resistant individuals. In this study, we examined the in vivo phenotypes as well as the insulin
signaling and action in cells from healthy subjects characterized as having normal or low
(50% of normal) IRS-1 expression.
Low expression of the key docking protein insulin receptor substrate-1 (IRS-1) has been found in fat cells from type 2 diabetic subjects as well as a cohort of non-diabetic but insulin-resistant individuals. In this study, we examined the in vivo phenotypes as well as the insulin signaling and action in cells from healthy subjects characterized as having normal or low (50% of normal) IRS-1 expression.
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