[HTML][HTML] Uncoupling of inflammation and insulin resistance by NF-κB in transgenic mice through elevated energy expenditure 2
T Tang, J Zhang, J Yin, J Staszkiewicz… - Journal of Biological …, 2010 - ASBMB
To study the metabolic activity of NF-κB, we investigated phenotypes of two different mouse
models with elevated NF-κB activities. The transcriptional activity of NF-κB is enhanced
either by overexpression of NF-κB p65 (RelA) in aP2-p65 mice or inactivation of NF-κB p50
(NF-κB1) through gene knock-out. In these models, energy expenditure was elevated in day
and night time without a change in locomotion. The mice were resistant to adulthood obesity
and diet-induced obesity without reduction in food intake. The adipose tissue growth and …
models with elevated NF-κB activities. The transcriptional activity of NF-κB is enhanced
either by overexpression of NF-κB p65 (RelA) in aP2-p65 mice or inactivation of NF-κB p50
(NF-κB1) through gene knock-out. In these models, energy expenditure was elevated in day
and night time without a change in locomotion. The mice were resistant to adulthood obesity
and diet-induced obesity without reduction in food intake. The adipose tissue growth and …