[HTML][HTML] IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice
EB Ahmed, T Wang, M Daniels, ML Alegre… - American journal of …, 2011 - Elsevier
Clinical correlations between bacterial infections and rejection suggest a hypothesis that
innate immune stimulation by bacterial infections results in the production of inflammatory
cytokine that facilitate bystander T-cell activation, increased alloreactivity and inhibition of
tolerance induction. Previous studies demonstrated that IFNβ produced during an infection
with a model bacterium, Listeria monocytogenes, prevented the induction of transplantation
tolerance in mice with anti-CD154 and donor-specific transfusion (DST)(1). We investigated …
innate immune stimulation by bacterial infections results in the production of inflammatory
cytokine that facilitate bystander T-cell activation, increased alloreactivity and inhibition of
tolerance induction. Previous studies demonstrated that IFNβ produced during an infection
with a model bacterium, Listeria monocytogenes, prevented the induction of transplantation
tolerance in mice with anti-CD154 and donor-specific transfusion (DST)(1). We investigated …