Molecular diagnosis of prostate cancer: PCA3 and TMPRSS2: ERG gene fusion
M Salagierski, JA Schalken - The Journal of urology, 2012 - Elsevier
PURPOSE: Widespread prostate specific antigen screening together with the increase in the
number of biopsy cores has led to increased prostate cancer incidence. Standard diagnostic
tools still cannot unequivocally predict prostate cancer progression, which often results in a
significant overtreatment rate. We present recent findings on PCA3 and TMPRSS: ERG
fusion, and describe their clinical implications and performance. MATERIALS AND
METHODS: The PubMed® database was searched for reports on PCA3 (130 articles) …
number of biopsy cores has led to increased prostate cancer incidence. Standard diagnostic
tools still cannot unequivocally predict prostate cancer progression, which often results in a
significant overtreatment rate. We present recent findings on PCA3 and TMPRSS: ERG
fusion, and describe their clinical implications and performance. MATERIALS AND
METHODS: The PubMed® database was searched for reports on PCA3 (130 articles) …