A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer
M Hanke, K Hoefig, H Merz, AC Feller, I Kausch… - … oncology: seminars and …, 2010 - Elsevier
OBJECTIVES: MicroRNAs have been shown to be related to specific types of malignant cell
growth. In case of urothelial bladder cancer (BCa), novel noninvasive diagnosis is
particularly required and it is attractive to consider, as urine is an easily available source for
molecular markers including RNA. In this context, we aimed to develop a clinically
applicable and sensitive protocol for the preparation and molecular analysis of low
molecular weight RNA from urine samples obtained from bladder cancer patients or healthy …
growth. In case of urothelial bladder cancer (BCa), novel noninvasive diagnosis is
particularly required and it is attractive to consider, as urine is an easily available source for
molecular markers including RNA. In this context, we aimed to develop a clinically
applicable and sensitive protocol for the preparation and molecular analysis of low
molecular weight RNA from urine samples obtained from bladder cancer patients or healthy …