Advancing age is frequented by the onset of a variety of hematological conditions
characterized by diminished homeostatic control of blood cell production. The fact that
upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic
control of all blood lineages, has implicated the involvement of these cells in the
pathophysiology of these conditions. Indeed, evidence from our group and others has
suggested that two of the most clinically significant age-associated hematological …