[HTML][HTML] IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques
H Xu, X Wang, DX Liu, T Moroney-Rasmussen… - Mucosal …, 2012 - Elsevier
Innate lymphoid cells (ILCs) are an emerging subset of lymphocytes involved in surveillance
against virally infected cells. Here, we show CD3− CD8 high lymphocytes in macaque blood
include major subsets of ILCs including natural killer (NK) cells expressing CD16, NKp46,
and NKG2A, but also populations of ILCs in mucosal tissues having different properties. One
ILC subset secreted interleukin (IL)-17 (ILC17), but these were restricted to mucosal tissues.
Some mucosal ILC17 cells expressed classical NK-cell markers, but little NKG2A or NKG2D …
against virally infected cells. Here, we show CD3− CD8 high lymphocytes in macaque blood
include major subsets of ILCs including natural killer (NK) cells expressing CD16, NKp46,
and NKG2A, but also populations of ILCs in mucosal tissues having different properties. One
ILC subset secreted interleukin (IL)-17 (ILC17), but these were restricted to mucosal tissues.
Some mucosal ILC17 cells expressed classical NK-cell markers, but little NKG2A or NKG2D …