The role of DNA fragmentation in apoptosis
CD Bortner, NBE Oldenburg, JA Cidlowski - Trends in cell biology, 1995 - cell.com
CD Bortner, NBE Oldenburg, JA Cidlowski
Trends in cell biology, 1995•cell.comThe formation of distinct DNA fragments of oligonucleosomal size (180–200 by lengths) is a
biochemical hallmark of apoptosis in many cells. Recent observations also suggest large
DNA fragments and even single-strand cleavage events occur during cell death. These
observations have raised many questions. What are the types of DNA cleavage observed
during apoptosis? What are the nucleases involved? And what is the role of these
nucleolytic events in apoptosis?
biochemical hallmark of apoptosis in many cells. Recent observations also suggest large
DNA fragments and even single-strand cleavage events occur during cell death. These
observations have raised many questions. What are the types of DNA cleavage observed
during apoptosis? What are the nucleases involved? And what is the role of these
nucleolytic events in apoptosis?
Abstract
The formation o f distinct DNA fragments of oligonucleosomal size (180–200 by lengths) is a biochemical hallmark of apoptosis in many cells. Recent observations also suggest large DNA fragments and even single-strand cleavage events occur during cell death. These observations have raised many questions. What are the types o f DNA cleavage observed during apoptosis? What are the nucleases involved? And what is the role o f these nucleolytic events in apoptosis?
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