[HTML][HTML] Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX …
JH Lee, Y Jin, G He, SX Zeng, YV Wang… - Journal of Biological …, 2012 - ASBMB
It has been known that p53 can be induced and activated by hypoxia, an abnormal condition
that often occurs in rapidly growing solid tumors or when normal tissues undergo ischemia.
Although the ATR-Chk1 kinase cascade was associated with hypoxia-induced p53
activation, molecules that directly link this hypoxia-ATR-Chk1 pathway to p53 activation
have been elusive. Here, we showed that hypoxia could induce phosphorylation of MDMX at
Ser-367 and enhance the binding of this phosphorylated MDMX to 14-3-3γ, consequently …
that often occurs in rapidly growing solid tumors or when normal tissues undergo ischemia.
Although the ATR-Chk1 kinase cascade was associated with hypoxia-induced p53
activation, molecules that directly link this hypoxia-ATR-Chk1 pathway to p53 activation
have been elusive. Here, we showed that hypoxia could induce phosphorylation of MDMX at
Ser-367 and enhance the binding of this phosphorylated MDMX to 14-3-3γ, consequently …