MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
E Van Rooij, EN Olson - Nature reviews Drug discovery, 2012 - nature.com
Nature reviews Drug discovery, 2012•nature.com
In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several
cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and
function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has
triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the
pharmacokinetic and pharmacodynamic properties of current antimiR designs and their
relevance to cardiovascular indications, and evaluate the opportunities and obstacles …
cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and
function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has
triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the
pharmacokinetic and pharmacodynamic properties of current antimiR designs and their
relevance to cardiovascular indications, and evaluate the opportunities and obstacles …
Abstract
In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.
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