Holey barrier: claudins and the regulation of brain endothelial permeability
K Matter, MS Balda - The Journal of cell biology, 2003 - rupress.org
K Matter, MS Balda
The Journal of cell biology, 2003•rupress.orgE ndothelial tight junctions (TJs) are an important functional part of the blood-brain barrier
(BBB). In this issue, demonstrate that claudin-5, a transmembrane protein of TJs, is a critical
determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not result
in a general breakdown of TJs but in a selective increase in paracellular permeability of
small molecules. This suggests that the BBB can be manipulated to allow selective diffusion
of small molecules and makes claudin-5 a possible target for the development of drugs for …
(BBB). In this issue, demonstrate that claudin-5, a transmembrane protein of TJs, is a critical
determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not result
in a general breakdown of TJs but in a selective increase in paracellular permeability of
small molecules. This suggests that the BBB can be manipulated to allow selective diffusion
of small molecules and makes claudin-5 a possible target for the development of drugs for …
Endothelial tight junctions (TJs) are an important functional part of the blood-brain barrier (BBB). In this issue, demonstrate that claudin-5, a transmembrane protein of TJs, is a critical determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not result in a general breakdown of TJs but in a selective increase in paracellular permeability of small molecules. This suggests that the BBB can be manipulated to allow selective diffusion of small molecules and makes claudin-5 a possible target for the development of drugs for this purpose.
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