[HTML][HTML] Silencer activity of NFATc2 in the interleukin-12 receptor β2 proximal promoter in human T helper cells
JGI van Rietschoten, HH Smits… - Journal of Biological …, 2001 - ASBMB
Interleukin 12 (IL-12) is a potent enhancer of interferon γ production by activated T cells. The
high-affinity IL-12 receptor (IL-12R) is a heterodimer of a β1 and a β2 subunit. Expression of
the signaling IL-12Rβ2 chain is usually low, as compared with the more abundant β1 chain,
and may be rate-limiting for IL-12 sensitivity. Little is known about the mechanisms
controllingIL-12Rβ2 gene expression. Reporter gene assays in IL-12Rβ2-expressing Jurkat
cells showed that truncation of the region from− 151 to− 61 abrogated promoter activity. The …
high-affinity IL-12 receptor (IL-12R) is a heterodimer of a β1 and a β2 subunit. Expression of
the signaling IL-12Rβ2 chain is usually low, as compared with the more abundant β1 chain,
and may be rate-limiting for IL-12 sensitivity. Little is known about the mechanisms
controllingIL-12Rβ2 gene expression. Reporter gene assays in IL-12Rβ2-expressing Jurkat
cells showed that truncation of the region from− 151 to− 61 abrogated promoter activity. The …