[HTML][HTML] Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains …
J Betz, M Bielaszewska, A Thies, HU Humpf… - Journal of lipid …, 2011 - ASBMB
Vascular damage caused by Shiga toxin (Stx)-producing Escherichia coli is largely
mediated by Stxs, which in particular, injure microvascular endothelial cells in the kidneys
and brain. The majority of Stxs preferentially bind to the glycosphingolipid (GSL)
globotriaosylceramide (Gb3Cer) and, to a lesser extent, to globotetraosylceramide
(Gb4Cer). As clustering of receptor GSLs in lipid rafts is a functional requirement for Stxs, we
analyzed the distribution of Gb3Cer and Gb4Cer to membrane microdomains of human …
mediated by Stxs, which in particular, injure microvascular endothelial cells in the kidneys
and brain. The majority of Stxs preferentially bind to the glycosphingolipid (GSL)
globotriaosylceramide (Gb3Cer) and, to a lesser extent, to globotetraosylceramide
(Gb4Cer). As clustering of receptor GSLs in lipid rafts is a functional requirement for Stxs, we
analyzed the distribution of Gb3Cer and Gb4Cer to membrane microdomains of human …