Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in
vertebrates they are known to participate in several developmental processes, including
angiogenesis, vasculogenesis, heart and central nervous system development. Over the last
decade, major progress in unraveling the molecular mechanisms that mediate regulation of
HIF proteins by oxygen tension has been reported, but our knowledge on their
developmental regulation during embryogenesis in model organisms is limited. Expression …